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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [49-170]' and Ligand = 'BDBM480542'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 [49-170]


(Homo sapiens (Human))		BDBM480542
PNG
(US10899769, Example 26a)
Show SMILES C[C@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)(F)F |r|
Show InChI InChI=1S/C27H27F3N6O2/c1-15-26(37)34(2)14-22-24(33-25(36(15)22)16-7-9-38-10-8-16)18-5-4-6-21-19(18)11-20(27(28,29)30)23(32-21)17-12-31-35(3)13-17/h4-6,11-13,15-16H,7-10,14H2,1-3H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...

US Patent US10899769 (2021)


BindingDB Entry DOI: 10.7270/Q2H41VJJ
More data for this
Ligand-Target Pair