Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'C-1-tetrahydrofolate synthase, cytoplasmic' and Ligand = 'BDBM50580112'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-1-tetrahydrofolate synthase, cytoplasmic (Homo sapiens)	BDBM50580112 (CHEMBL5077748) Show SMILES Cn1c(N[C@H]2CC[C@H](O)CC2)nc2n(C)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c(=O)c12 |r,wU:4.3,wD:7.7,(14.78,-9.97,;14.31,-8.5,;15.22,-7.26,;16.76,-7.27,;17.54,-5.94,;16.78,-4.61,;17.56,-3.28,;19.1,-3.29,;19.89,-1.97,;19.86,-4.63,;19.08,-5.95,;14.32,-6,;12.85,-6.47,;11.52,-5.7,;11.52,-4.16,;10.18,-6.47,;8.84,-5.7,;10.18,-8.01,;8.85,-8.78,;7.52,-8.01,;7.51,-6.46,;6.18,-5.7,;4.85,-6.47,;3.52,-5.7,;4.85,-8.01,;3.51,-8.78,;6.18,-8.78,;11.52,-8.78,;11.52,-10.32,;12.84,-8.02,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00663 BindingDB Entry DOI: 10.7270/Q2B56PKM
					More data for this Ligand-Target Pair