Found 2 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50359099' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359099
(CHEMBL1922816)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccc(Cl)cc1 |(-8.82,-24.84,;-7.49,-25.62,;-6.15,-24.85,;-7.49,-27.16,;-8.83,-27.92,;-8.83,-29.46,;-10.17,-30.22,;-10.17,-31.76,;-8.84,-32.53,;-7.51,-31.77,;-7.5,-30.22,;-8.85,-34.07,;-10.09,-34.98,;-9.61,-36.45,;-8.08,-36.44,;-7.05,-37.58,;-5.54,-37.26,;-5.07,-35.79,;-6.1,-34.65,;-7.6,-34.98,;-6.16,-27.93,;-6.18,-29.47,;-4.85,-30.25,;-3.51,-29.49,;-3.5,-27.94,;-4.84,-27.16,;-2.18,-30.26,;-2.19,-31.8,;-.85,-29.5,;.48,-30.28,;1.82,-29.52,;3.14,-30.31,;4.48,-29.55,;4.49,-28,;5.83,-27.24,;3.16,-27.23,;1.82,-27.99,)| Show InChI InChI=1S/C30H35ClN4O2/c31-23-10-5-20(6-11-23)7-14-28(36)35-17-15-22(16-18-35)29(30(32)37)34-24-12-8-21(9-13-24)26-19-33-27-4-2-1-3-25(26)27/h1-7,10-11,14,19,21-22,24,29,33-34H,8-9,12-13,15-18H2,(H2,32,37)/b14-7+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR2 |
Bioorg Med Chem Lett 21: 7496-501 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.113
BindingDB Entry DOI: 10.7270/Q22J6C9M |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359099
(CHEMBL1922816)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccc(Cl)cc1 |(-8.82,-24.84,;-7.49,-25.62,;-6.15,-24.85,;-7.49,-27.16,;-8.83,-27.92,;-8.83,-29.46,;-10.17,-30.22,;-10.17,-31.76,;-8.84,-32.53,;-7.51,-31.77,;-7.5,-30.22,;-8.85,-34.07,;-10.09,-34.98,;-9.61,-36.45,;-8.08,-36.44,;-7.05,-37.58,;-5.54,-37.26,;-5.07,-35.79,;-6.1,-34.65,;-7.6,-34.98,;-6.16,-27.93,;-6.18,-29.47,;-4.85,-30.25,;-3.51,-29.49,;-3.5,-27.94,;-4.84,-27.16,;-2.18,-30.26,;-2.19,-31.8,;-.85,-29.5,;.48,-30.28,;1.82,-29.52,;3.14,-30.31,;4.48,-29.55,;4.49,-28,;5.83,-27.24,;3.16,-27.23,;1.82,-27.99,)| Show InChI InChI=1S/C30H35ClN4O2/c31-23-10-5-20(6-11-23)7-14-28(36)35-17-15-22(16-18-35)29(30(32)37)34-24-12-8-21(9-13-24)26-19-33-27-4-2-1-3-25(26)27/h1-7,10-11,14,19,21-22,24,29,33-34H,8-9,12-13,15-18H2,(H2,32,37)/b14-7+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV
US Patent
| Assay Description
MCP-1 Receptor Binding Assay in THP-1 Cells Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va.,... |
US Patent US8921559 (2014)
BindingDB Entry DOI: 10.7270/Q270804M |
More data for this
Ligand-Target Pair | |
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