Found 2 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50359101' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359101
(CHEMBL1922814)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cccc(F)c1 |(41.98,-9.05,;43.32,-9.83,;44.65,-9.06,;43.31,-11.37,;41.97,-12.13,;41.97,-13.67,;40.63,-14.44,;40.63,-15.97,;41.96,-16.75,;43.3,-15.98,;43.3,-14.43,;41.96,-18.29,;40.71,-19.2,;41.19,-20.66,;42.73,-20.65,;43.76,-21.79,;45.26,-21.47,;45.73,-20,;44.7,-18.86,;43.2,-19.19,;44.64,-12.14,;44.63,-13.68,;45.95,-14.46,;47.29,-13.7,;47.3,-12.16,;45.97,-11.37,;48.62,-14.48,;48.61,-16.02,;49.96,-13.71,;51.29,-14.49,;52.63,-13.73,;52.63,-12.2,;53.96,-11.44,;55.3,-12.22,;55.29,-13.76,;56.61,-14.54,;53.95,-14.52,)| Show InChI InChI=1S/C30H35FN4O2/c31-23-5-3-4-20(18-23)8-13-28(36)35-16-14-22(15-17-35)29(30(32)37)34-24-11-9-21(10-12-24)26-19-33-27-7-2-1-6-25(26)27/h1-8,13,18-19,21-22,24,29,33-34H,9-12,14-17H2,(H2,32,37)/b13-8+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV
US Patent
| Assay Description MCP-1 Receptor Binding Assay in THP-1 Cells Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va.,... |
US Patent US8921559 (2014)
BindingDB Entry DOI: 10.7270/Q270804M |
More data for this Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359101
(CHEMBL1922814)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cccc(F)c1 |(41.98,-9.05,;43.32,-9.83,;44.65,-9.06,;43.31,-11.37,;41.97,-12.13,;41.97,-13.67,;40.63,-14.44,;40.63,-15.97,;41.96,-16.75,;43.3,-15.98,;43.3,-14.43,;41.96,-18.29,;40.71,-19.2,;41.19,-20.66,;42.73,-20.65,;43.76,-21.79,;45.26,-21.47,;45.73,-20,;44.7,-18.86,;43.2,-19.19,;44.64,-12.14,;44.63,-13.68,;45.95,-14.46,;47.29,-13.7,;47.3,-12.16,;45.97,-11.37,;48.62,-14.48,;48.61,-16.02,;49.96,-13.71,;51.29,-14.49,;52.63,-13.73,;52.63,-12.2,;53.96,-11.44,;55.3,-12.22,;55.29,-13.76,;56.61,-14.54,;53.95,-14.52,)| Show InChI InChI=1S/C30H35FN4O2/c31-23-5-3-4-20(18-23)8-13-28(36)35-16-14-22(15-17-35)29(30(32)37)34-24-11-9-21(10-12-24)26-19-33-27-7-2-1-6-25(26)27/h1-8,13,18-19,21-22,24,29,33-34H,9-12,14-17H2,(H2,32,37)/b13-8+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Antagonist activity at human CCR2 |
Bioorg Med Chem Lett 21: 7496-501 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.113 BindingDB Entry DOI: 10.7270/Q22J6C9M |
More data for this Ligand-Target Pair | |