Found 2 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50359109' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359109
(CHEMBL1922806)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccccc1 |(-8.41,5.29,;-7.08,4.51,;-5.74,5.28,;-7.08,2.97,;-8.42,2.21,;-8.42,.67,;-9.76,-.09,;-9.76,-1.63,;-8.43,-2.4,;-7.09,-1.64,;-7.09,-.09,;-8.44,-3.94,;-9.68,-4.85,;-9.2,-6.32,;-7.66,-6.31,;-6.64,-7.45,;-5.13,-7.13,;-4.66,-5.66,;-5.69,-4.52,;-7.19,-4.84,;-5.75,2.2,;-5.76,.66,;-4.44,-.11,;-3.1,.65,;-3.09,2.19,;-4.42,2.97,;-1.77,-.13,;-1.78,-1.67,;-.43,.63,;.9,-.15,;2.23,.61,;3.56,-.17,;4.89,.59,;4.91,2.13,;3.57,2.91,;2.24,2.14,)| Show InChI InChI=1S/C30H36N4O2/c31-30(36)29(23-16-18-34(19-17-23)28(35)15-10-21-6-2-1-3-7-21)33-24-13-11-22(12-14-24)26-20-32-27-9-5-4-8-25(26)27/h1-10,15,20,22-24,29,32-33H,11-14,16-19H2,(H2,31,36)/b15-10+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR2 |
Bioorg Med Chem Lett 21: 7496-501 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.113
BindingDB Entry DOI: 10.7270/Q22J6C9M |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359109
(CHEMBL1922806)Show SMILES NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccccc1 |(-8.41,5.29,;-7.08,4.51,;-5.74,5.28,;-7.08,2.97,;-8.42,2.21,;-8.42,.67,;-9.76,-.09,;-9.76,-1.63,;-8.43,-2.4,;-7.09,-1.64,;-7.09,-.09,;-8.44,-3.94,;-9.68,-4.85,;-9.2,-6.32,;-7.66,-6.31,;-6.64,-7.45,;-5.13,-7.13,;-4.66,-5.66,;-5.69,-4.52,;-7.19,-4.84,;-5.75,2.2,;-5.76,.66,;-4.44,-.11,;-3.1,.65,;-3.09,2.19,;-4.42,2.97,;-1.77,-.13,;-1.78,-1.67,;-.43,.63,;.9,-.15,;2.23,.61,;3.56,-.17,;4.89,.59,;4.91,2.13,;3.57,2.91,;2.24,2.14,)| Show InChI InChI=1S/C30H36N4O2/c31-30(36)29(23-16-18-34(19-17-23)28(35)15-10-21-6-2-1-3-7-21)33-24-13-11-22(12-14-24)26-20-32-27-9-5-4-8-25(26)27/h1-10,15,20,22-24,29,32-33H,11-14,16-19H2,(H2,31,36)/b15-10+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV
US Patent
| Assay Description
MCP-1 Receptor Binding Assay in THP-1 Cells Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va.,... |
US Patent US8921559 (2014)
BindingDB Entry DOI: 10.7270/Q270804M |
More data for this
Ligand-Target Pair | |
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