BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with Target = 'CREB-binding protein' and Ligand = 'BDBM50365262'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...				US Patent US10617680 (2020) BindingDB Entry DOI: 10.7270/Q27S7RT7
CELGENE QUANTICEL RESEARCH, INC. US Patent					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...				US Patent US10202360 (2019) BindingDB Entry DOI: 10.7270/Q2R213HG
CELGENE QUANTICEL RESEARCH, INC. US Patent					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity CBP (unknown origin) incubated for 1 hr by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01851 BindingDB Entry DOI: 10.7270/Q2HD80K2
TBA					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Japan Science and Technology Agency Curated by ChEMBL					Assay Description Displacement of acetylated histone peptide from CREBBP by luminescence proximity homogenous assay				Bioorg Med Chem 20: 1887-92 (2012) Article DOI: 10.1016/j.bmc.2012.01.018 BindingDB Entry DOI: 10.7270/Q2TX3FTN
Japan Science and Technology Agency Curated by ChEMBL					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 \| (S)-JQ1 (1) \| CHEMBL1957266 \| JQ1 \| US10...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assay				J Med Chem 63: 5242-5256 (2020) Article DOI: 10.1021/acs.jmedchem.0c00035 BindingDB Entry DOI: 10.7270/Q2PK0KMS
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair