BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Calpain-1 catalytic subunit' and Ligand = 'BDBM50258317'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Calpain-1 catalytic subunit (Homo sapiens (Human))	BDBM50258317 (CHEMBL4072233) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience Research, AbbVie Deutschland GmbH& Co. KG , Knollstrasse, 67061 Ludwigshafen, Germany. Curated by ChEMBL					Assay Description Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assay				J Med Chem 60: 7123-7138 (2017) Article DOI: 10.1021/acs.jmedchem.7b00731 BindingDB Entry DOI: 10.7270/Q2Q242P4
					More data for this Ligand-Target Pair
Calpain-1 catalytic subunit (Rattus norvegicus)	BDBM50258317 (CHEMBL4072233) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience Research, AbbVie Deutschland GmbH& Co. KG , Knollstrasse, 67061 Ludwigshafen, Germany. Curated by ChEMBL					Assay Description Inhibition of calpain-1 in rat hippocampal slices assessed as prevention of NMDA-induced spectrin cleavage preincubated for 30 mins followed by NMDA ...				J Med Chem 60: 7123-7138 (2017) Article DOI: 10.1021/acs.jmedchem.7b00731 BindingDB Entry DOI: 10.7270/Q2Q242P4
					More data for this Ligand-Target Pair