BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 1' and Ligand = 'BDBM13075'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University Curated by ChEMBL					Assay Description Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration method				Bioorg Med Chem 18: 930-8 (2010) Article DOI: 10.1016/j.bmc.2009.11.031 BindingDB Entry DOI: 10.7270/Q2FQ9XK3
Dumlupinar University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description The carbonic anhydrase activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al....				J Enzyme Inhib Med Chem 26: 104-14 (2011) Article DOI: 10.3109/14756361003733639 BindingDB Entry DOI: 10.7270/Q2PC318R
Dumlupinar University					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	7.4	n/a
Dumlupinar University					Assay Description The carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of the 4-nitrophenylacetate (NPA) to the 4-nitrophenylate...				J Enzyme Inhib Med Chem 26: 104-14 (2011) Article DOI: 10.3109/14756361003733639 BindingDB Entry DOI: 10.7270/Q2PC318R
Dumlupinar University					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University Curated by ChEMBL					Assay Description Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometry				Bioorg Med Chem 18: 930-8 (2010) Article DOI: 10.1016/j.bmc.2009.11.031 BindingDB Entry DOI: 10.7270/Q2FQ9XK3
Dumlupinar University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University Curated by ChEMBL					Assay Description Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysis				Bioorg Med Chem 18: 930-8 (2010) Article DOI: 10.1016/j.bmc.2009.11.031 BindingDB Entry DOI: 10.7270/Q2FQ9XK3
Dumlupinar University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dumlupinar University					Assay Description The method for determination of the Ki values is described elsewhere [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; B�lb�l et al., J. ...				J Enzyme Inhib Med Chem 26: 104-14 (2011) Article DOI: 10.3109/14756361003733639 BindingDB Entry DOI: 10.7270/Q2PC318R
Dumlupinar University					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Vilnius University Curated by ChEMBL					Assay Description Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as observed dissociation constant...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111825 BindingDB Entry DOI: 10.7270/Q2VX0KS1
Vilnius University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Vilnius University Curated by ChEMBL					Assay Description Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli in presence of ANS by fluorescent thermal shift assay				Eur J Med Chem 156: 61-78 (2018) Article DOI: 10.1016/j.ejmech.2018.06.059 BindingDB Entry DOI: 10.7270/Q2805559
Vilnius University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
Vilnius University Curated by ChEMBL					Assay Description Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli assessed as intrinsic Kd in presence of ANS by fluorescent t...				Eur J Med Chem 156: 61-78 (2018) Article DOI: 10.1016/j.ejmech.2018.06.059 BindingDB Entry DOI: 10.7270/Q2805559
Vilnius University Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM13075 (2,4-dichloro-5-sulfamoylbenzoic acid \| 2000-01951 ...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
Vilnius University Curated by ChEMBL					Assay Description Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as kinetic dissociation constant ...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111825 BindingDB Entry DOI: 10.7270/Q2VX0KS1
Vilnius University Curated by ChEMBL					More data for this Ligand-Target Pair