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Found 1 hit Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 2' and Ligand = 'BDBM50211508'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Carbonic anhydrase 2


(Homo sapiens (Human))		BDBM50211508
PNG
(CHEMBL3954963)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccccc3)onc2-c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C23H16Cl2N4O5S/c24-14-6-11-17(18(25)12-14)20-19(22(31)27-15-7-9-16(10-8-15)35(26,32)33)23(34-29-20)28-21(30)13-4-2-1-3-5-13/h1-12H,(H,27,31)(H,28,30)(H2,26,32,33)
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 246n/an/an/an/an/an/an/an/a



Abant Izzet Baysal University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay

Bioorg Med Chem 25: 1456-1464 (2017)


Article DOI: 10.1016/j.bmc.2017.01.008
BindingDB Entry DOI: 10.7270/Q2MS3VXQ
More data for this
Ligand-Target Pair