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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 4' and Ligand = 'BDBM50211588'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Carbonic anhydrase 4


(Homo sapiens (Human))		BDBM50211588
PNG
(CHEMBL3894919)
Show SMILES Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1c(Cl)cccc1Cl |(13.16,-14.5,;14.63,-14.96,;15.1,-16.42,;16.64,-16.42,;17.11,-14.95,;15.86,-14.06,;15.86,-12.52,;17.19,-11.75,;14.53,-11.76,;14.52,-10.22,;15.85,-9.45,;15.85,-7.91,;14.52,-7.14,;13.19,-7.91,;13.19,-9.45,;14.51,-5.6,;15.86,-4.83,;12.96,-5.6,;13.73,-4.26,;18.65,-14.95,;19.42,-13.62,;18.63,-12.28,;20.96,-13.61,;21.74,-14.95,;20.97,-16.29,;19.43,-16.29,;18.65,-17.63,)|
Show InChI InChI=1S/C16H12Cl2N4O4S/c17-10-2-1-3-11(18)12(10)14-13(15(19)26-22-14)16(23)21-8-4-6-9(7-5-8)27(20,24)25/h1-7H,19H2,(H,21,23)(H2,20,24,25)
PDB
MMDB

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 146n/an/an/an/an/an/an/an/a



Abant Izzet Baysal University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 4 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay

Bioorg Med Chem 25: 1456-1464 (2017)


Article DOI: 10.1016/j.bmc.2017.01.008
BindingDB Entry DOI: 10.7270/Q2MS3VXQ
More data for this
Ligand-Target Pair