Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]' and Ligand = 'BDBM238903'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human))	BDBM238903 (US9403827, 5) Show SMILES CC(C)N1C2C(N(C(=O)N=C2N=C1Br)c1cccc(Cl)c1F)c1ccc(Cl)cc1 |c:9,12| Show InChI InChI=1S/C20H16BrCl2FN4O/c1-10(2)27-17-16(11-6-8-12(22)9-7-11)28(14-5-3-4-13(23)15(14)24)20(29)26-18(17)25-19(27)21/h3-10,16-17H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...				US Patent US9403827 (2016) BindingDB Entry DOI: 10.7270/Q2Z31XKH
					More data for this Ligand-Target Pair