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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]' and Ligand = 'BDBM238917'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]


(Homo sapiens (Human))		BDBM238917
PNG
(US9403827, 19)
Show SMILES COc1ncc(-c2nc3NC(=O)N(C(c3n2C(C)C)c2ccc(Cl)c(F)c2)c2cc(Cl)c(=O)n(C)c2)c(OC)n1
Show InChI InChI=1S/C26H24Cl2FN7O4/c1-12(2)35-20-19(13-6-7-16(27)18(29)8-13)36(14-9-17(28)24(37)34(3)11-14)26(38)32-21(20)31-22(35)15-10-30-25(40-5)33-23(15)39-4/h6-12,19H,1-5H3,(H,32,38)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 930n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...

US Patent US9403827 (2016)


BindingDB Entry DOI: 10.7270/Q2Z31XKH
More data for this
Ligand-Target Pair