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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]' and Ligand = 'BDBM238922'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]


(Homo sapiens (Human))		BDBM238922
PNG
(US9403827, 24)
Show SMILES COc1nc(ncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C27H27Cl2FN8O3/c1-13(2)37-21-20(14-7-8-17(29)18(30)9-14)38(19-10-15(28)12-36(5)25(19)39)27(40)33-22(21)32-23(37)16-11-31-26(35(3)4)34-24(16)41-6/h7-13,20H,1-6H3,(H,33,40)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 748n/an/an/an/an/a25



NOVARTIS AG

US Patent


Assay Description
Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...

US Patent US9403827 (2016)


BindingDB Entry DOI: 10.7270/Q2Z31XKH
More data for this
Ligand-Target Pair