BindingDB PrimarySearch

Found 3 hits Enz. Inhib. hit(s) with Target = 'Chitotriosidase-1' and Ligand = 'BDBM349958'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Chitotriosidase-1 (Homo sapiens (Human))	BDBM349958 ((5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...				US Patent US10208020 (2019) BindingDB Entry DOI: 10.7270/Q2RR21C4
OncoArendi Therapeutics S.A. US Patent					More data for this Ligand-Target Pair
Chitotriosidase-1 (Homo sapiens (Human))	BDBM349958 ((5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...				US Patent US10538508 (2020) BindingDB Entry DOI: 10.7270/Q2W37ZQC
OncoArendi Therapeutics S.A. US Patent					More data for this Ligand-Target Pair
Chitotriosidase-1 (Homo sapiens (Human))	BDBM349958 ((5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q22N54MD
Schering-Plough Research Institute					More data for this Ligand-Target Pair