Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2' and Ligand = 'BDBM387082'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2 (Homo sapiens (Human))	BDBM387082 (4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...) Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...				J Med Chem 51: 1681-94 (2008) BindingDB Entry DOI: 10.7270/Q2F1921P
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