BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor XII' and Ligand = 'BDBM476373'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor XII


(Homo sapiens (Human))		BDBM476373
PNG
(4-methylquinazolin-8-yl (3S)-4-(N,3- dicyclohexyl-...)
Show SMILES Cc1ncnc2c(OC(=O)N3CCN([C@@H](C3)C(=O)NCc3cccs3)C(=O)[C@@H](CC3CCCCC3)NC3CCCCC3)cccc12 |r|
Show InChI InChI=1S/C35H46N6O4S/c1-24-28-15-8-16-31(32(28)38-23-37-24)45-35(44)40-17-18-41(30(22-40)33(42)36-21-27-14-9-19-46-27)34(43)29(20-25-10-4-2-5-11-25)39-26-12-6-3-7-13-26/h8-9,14-16,19,23,25-26,29-30,39H,2-7,10-13,17-18,20-22H2,1H3,(H,36,42)/t29-,30+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...

US Patent US10875851 (2020)


BindingDB Entry DOI: 10.7270/Q2JD50W8
More data for this
Ligand-Target Pair