BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor XII' and Ligand = 'BDBM476407'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor XII


(Homo sapiens (Human))		BDBM476407
PNG
(2-chlorophenyl (3S)-4-[(2R)-2- (cyclohexylamino)-2...)
Show SMILES CC(C)S(=O)(=O)N1CCC(CC1)[C@@H](NC1CCCCC1)C(=O)N1CCN(C[C@H]1C(=O)NCc1cccs1)C(=O)Oc1ccccc1Cl |r|
Show InChI InChI=1S/C33H46ClN5O6S2/c1-23(2)47(43,44)38-16-14-24(15-17-38)30(36-25-9-4-3-5-10-25)32(41)39-19-18-37(33(42)45-29-13-7-6-12-27(29)34)22-28(39)31(40)35-21-26-11-8-20-46-26/h6-8,11-13,20,23-25,28,30,36H,3-5,9-10,14-19,21-22H2,1-2H3,(H,35,40)/t28-,30+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...

US Patent US10875851 (2020)


BindingDB Entry DOI: 10.7270/Q2JD50W8
More data for this
Ligand-Target Pair