Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Binding affinity to the cloned human corticotropin releasing factor receptor 1 | Bioorg Med Chem Lett 14: 3669-73 (2004) Article DOI: 10.1016/j.bmcl.2004.05.019 BindingDB Entry DOI: 10.7270/Q2T72GWP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor | J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells | Bioorg Med Chem Lett 8: 2067-70 (1999) BindingDB Entry DOI: 10.7270/Q2125RTC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor | J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmc.2022.116614 BindingDB Entry DOI: 10.7270/Q21Z48DS | ||||||||||||
More data for this Ligand-Target Pair |