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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50234473'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50234473
PNG
(CHEMBL4091442)
Show SMILES CCN(CCO)c1ccc(Br)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C20H24BrClN4O2/c1-5-26(8-9-27)15-7-6-14(21)18-19(15)25(3)20(24-18)23-17-12(2)10-13(22)11-16(17)28-4/h6-7,10-11,27H,5,8-9H2,1-4H3,(H,23,24)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition meas...

Bioorg Med Chem 25: 1556-1570 (2017)


Article DOI: 10.1016/j.bmc.2016.11.011
BindingDB Entry DOI: 10.7270/Q23R0W4P
More data for this
Ligand-Target Pair