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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cruzipain' and Ligand = 'BDBM50282986'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cruzipain


(Trypanosoma cruzi)		BDBM50282986
PNG
(CHEMBL3786939)
Show SMILES C\C(=N/Nc1nc(C)cs1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H11Cl2N3S/c1-7-6-18-12(15-7)17-16-8(2)9-3-4-10(13)11(14)5-9/h3-6H,1-2H3,(H,15,17)/b16-8+
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Universidade Federal de Pernambuco - UFPE

Curated by ChEMBL


Assay Description
Inhibition of recombinant Trypanosoma cruzi cruzain preincubated for 10 mins followed by Z-FR-AMC substrate addition measured for 5 mins at 12 secs t...

Eur J Med Chem 141: 346-361 (2017)


Article DOI: 10.1016/j.ejmech.2017.09.047
BindingDB Entry DOI: 10.7270/Q2F1927C
More data for this
Ligand-Target Pair