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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase [155-522]' and Ligand = 'BDBM457583'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclic GMP-AMP synthase [155-522]


(Homo sapiens (Human))		BDBM457583
PNG
(US10738056, Compound D1028)
Show SMILES CO[C@](c1nnc(o1)-c1c(C)[nH]c2c(c(nn2c1=O)C(F)(F)F)-c1ccccc1)(c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C25H17F6N5O3/c1-13-16(20-33-34-22(39-20)23(38-2,25(29,30)31)15-11-7-4-8-12-15)21(37)36-19(32-13)17(14-9-5-3-6-10-14)18(35-36)24(26,27)28/h3-12,32H,1-2H3/t23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<20n/an/an/an/an/an/a



Aduro BioTech Inc.

US Patent


Assay Description
Protein was expressed and purified from E. coli BL21 DE3 Rosetta 2 (EMD Millipore) cells using standard techniques. Cells were grown in 2x yeast extr...

US Patent US10738056 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PR3
More data for this
Ligand-Target Pair