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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-C/Cyclin-dependent kinase 8' and Ligand = 'BDBM50260954'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-C/Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50260954
PNG
(CHEMBL4070689)
Show SMILES Cc1c(c[nH]c1C(N)=O)-c1ccncc1C
Show InChI InChI=1S/C12H13N3O/c1-7-5-14-4-3-9(7)10-6-15-11(8(10)2)12(13)16/h3-6,15H,1-2H3,(H2,13,16)
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KEGG

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Medicinal Chemistry, Roche Innovation Center Shanghai, Bldg 5, 720 Cailun Road, Shanghai 201203, China. Electronic address: cyrus.han@roche.com.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length His-tagged human CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...

Bioorg Med Chem Lett 27: 4488-4492 (2017)


Article DOI: 10.1016/j.bmcl.2017.07.080
BindingDB Entry DOI: 10.7270/Q2NP26W9
More data for this
Ligand-Target Pair