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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 2/G1/S-specific cyclin-E1' and Ligand = 'BDBM50468216'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1


(Homo sapiens (Human))		BDBM50468216
PNG
(CHEMBL4279331)
Show SMILES CC1c2c(c(nn2CC1(C)C)-c1ccccc1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C22H21N3O/c1-14-21-19(15-8-10-17(26)11-9-15)20(24-25(21)13-22(14,2)3)18-7-5-4-6-16(18)12-23/h4-11,14,26H,13H2,1-3H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.20E+4n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany AS CR

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/cyclin E expressed in Sf9 insect cells using histone H1 as substrate in presence of [gamma-33P]ATP

Eur J Med Chem 127: 632-642 (2017)


Article DOI: 10.1016/j.ejmech.2017.01.018
BindingDB Entry DOI: 10.7270/Q29Z97MF
More data for this
Ligand-Target Pair