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Target
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Compile Data Set for Download or QSAR
Found
3
hits Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 4/G1/S-specific cyclin-D1' and Ligand = 'BDBM498185'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human))
BDBM498185
(US11014911, Example 13 | US11718603, Example 13 | ...)
Show SMILES
COCc1cc(C(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)C)n(C)n1 |r|
Show InChI
PDB
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MCE
PC cid
PC sid
UniChem
US Patent
110
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
US Patent
Assay Description
The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...
US Patent
US11014911 (2021)
BindingDB Entry DOI:
10.7270/Q23N26H2
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human))
BDBM498185
(US11014911, Example 13 | US11718603, Example 13 | ...)
Show SMILES
COCc1cc(C(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)C)n(C)n1 |r|
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
MCE
PC cid
PC sid
UniChem
238
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
BindingDB Entry DOI:
10.7270/Q22F7SJ2
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human))
BDBM498185
(US11014911, Example 13 | US11718603, Example 13 | ...)
Show SMILES
COCc1cc(C(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)C)n(C)n1 |r|
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
MCE
PC cid
PC sid
UniChem
243
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
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