Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Cystic fibrosis transmembrane conductance regulator' and Ligand = 'BDBM50290142'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50290142 (CHEMBL3745838) Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2CCN(Cc3ccc(Cl)cc3)Cc12)-c1ccccn1 Show InChI InChI=1S/C26H29ClN6O/c1-18(34)29-21-9-14-33(15-10-21)26-22-17-32(16-19-5-7-20(27)8-6-19)13-11-23(22)30-25(31-26)24-4-2-3-12-28-24/h2-8,12,21H,9-11,13-17H2,1H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	708	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by for...				Eur J Med Chem 144: 179-200 (2018) Article DOI: 10.1016/j.ejmech.2017.12.030 BindingDB Entry DOI: 10.7270/Q20K2C4K
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50290142 (CHEMBL3745838) Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2CCN(Cc3ccc(Cl)cc3)Cc12)-c1ccccn1 Show InChI InChI=1S/C26H29ClN6O/c1-18(34)29-21-9-14-33(15-10-21)26-22-17-32(16-19-5-7-20(27)8-6-19)13-11-23(22)30-25(31-26)24-4-2-3-12-28-24/h2-8,12,21H,9-11,13-17H2,1H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
Siena Biotech S.p.A. Curated by ChEMBL					Assay Description Corrector activity at human CFTR F508 deletion mutant expressed in human A549 cells incubated for 25 mins by YFP-based fluorescence analysis				J Med Chem 58: 9697-711 (2015) Article DOI: 10.1021/acs.jmedchem.5b00771 BindingDB Entry DOI: 10.7270/Q2VD72FT
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50290142 (CHEMBL3745838) Show SMILES CC(=O)NC1CCN(CC1)c1nc(nc2CCN(Cc3ccc(Cl)cc3)Cc12)-c1ccccn1 Show InChI InChI=1S/C26H29ClN6O/c1-18(34)29-21-9-14-33(15-10-21)26-22-17-32(16-19-5-7-20(27)8-6-19)13-11-23(22)30-25(31-26)24-4-2-3-12-28-24/h2-8,12,21H,9-11,13-17H2,1H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
Siena Biotech S.p.A. Curated by ChEMBL					Assay Description Corrector activity at human CFTR F508 deletion mutant expressed in FRT cells incubated for 25 mins with forskolin by YFP-based fluorescence analysis ...				J Med Chem 58: 9697-711 (2015) Article DOI: 10.1021/acs.jmedchem.5b00771 BindingDB Entry DOI: 10.7270/Q2VD72FT
					More data for this Ligand-Target Pair