Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50343306 (1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human D2 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 20: 759-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.032 BindingDB Entry DOI: 10.7270/Q2CC11XQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50343306 (1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 561 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation counting | J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C | |||||||||||
More data for this Ligand-Target Pair |