Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA (cytosine-5)-methyltransferase 1 (Homo sapiens (Human)) | BDBM50389497![]() (CHEMBL1564869) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of DNMT (unknown origin) by densitometric analysis | Citation and Details Article DOI: 10.1016/j.bmc.2021.116324 BindingDB Entry DOI: 10.7270/Q2R49VK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (Homo sapiens (Human)) | BDBM50389497![]() (CHEMBL1564869) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biot... | J Med Chem 58: 2569-83 (2015) Article DOI: 10.1021/jm500843d BindingDB Entry DOI: 10.7270/Q24T6M36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (Homo sapiens (Human)) | BDBM50389497![]() (CHEMBL1564869) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Pierre et Marie Curie-Paris 6 Curated by ChEMBL | Assay Description Inhibition of human recombinant DNMT1 expressed in H19 cells assessed as inhibition of tritiated methyl incorporation from [3H]-labeled AdoMet into h... | J Med Chem 57: 421-34 (2014) Article DOI: 10.1021/jm401419p BindingDB Entry DOI: 10.7270/Q2QN69Q3 | |||||||||||
More data for this Ligand-Target Pair |