Found 44 hits Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit A/B' and Ligand = 'BDBM21690' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128648 BindingDB Entry DOI: 10.7270/Q2MC942Z |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Gdansk
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase super-coiling activity using relaxed pNO1 DNA as substrate incubated for 30 mins by fluorescence assay |
Eur J Med Chem 179: 576-590 (2019)
Article DOI: 10.1016/j.ejmech.2019.06.071 BindingDB Entry DOI: 10.7270/Q2T1573J |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase after 1 hr by agarose gel electrophoresis |
Eur J Med Chem 97: 94-103 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.058 BindingDB Entry DOI: 10.7270/Q2ZG6TZW |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hawai'i at Hilo
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysis |
J Med Chem 57: 8398-420 (2014)
Article DOI: 10.1021/jm500853v BindingDB Entry DOI: 10.7270/Q25M679K |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Escherichia coli DNA gyrase using relaxed PBR322 plasmid DNA as substrate incubated for 30 mins by ethidium bromide staining based agar... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00856 BindingDB Entry DOI: 10.7270/Q2FT8QN5 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli gyrase |
J Med Chem 49: 6435-8 (2006)
Article DOI: 10.1021/jm060505l BindingDB Entry DOI: 10.7270/Q21N80RC |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128499 BindingDB Entry DOI: 10.7270/Q2X06C35 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assay |
J Med Chem 57: 9078-95 (2014)
Article DOI: 10.1021/jm501174m BindingDB Entry DOI: 10.7270/Q2F76FB6 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Inhibition of reconstituted Escherichia coli DNA gyrase subunit AB assessed as reduction of DNA supercoiling activity using pBR322 DNA substrate |
Antimicrob Agents Chemother 52: 1382-90 (2008)
Article DOI: 10.1128/AAC.01551-07 BindingDB Entry DOI: 10.7270/Q2348KKM |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922 |
J Med Chem 49: 39-42 (2006)
Article DOI: 10.1021/jm051066d BindingDB Entry DOI: 10.7270/Q24B30W3 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against wild type Escherichia coli gyrase |
Bioorg Med Chem Lett 16: 1272-6 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.065 BindingDB Entry DOI: 10.7270/Q22R3R76 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi R&D
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase A2B2 using relaxed pNO1 as substrate |
J Med Chem 61: 3565-3581 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01892 BindingDB Entry DOI: 10.7270/Q2765HX2 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresis |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112222 BindingDB Entry DOI: 10.7270/Q2X06BPC |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei... |
J Med Chem 63: 7773-7816 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00347 BindingDB Entry DOI: 10.7270/Q2MW2MQS |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
| Assay Description Inhibitory activity against DNA gyrase enzyme was determined by supercoiling assay with Escherichia coli DNA gyrase |
Bioorg Med Chem Lett 13: 4229-33 (2003)
BindingDB Entry DOI: 10.7270/Q2GX49Z2 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d2md00049k BindingDB Entry DOI: 10.7270/Q2R2159M |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 661 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.117004 BindingDB Entry DOI: 10.7270/Q2183BM1 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Escherichia coli DNA gyrase supercoiling activity using pBR322 as substrate incubated for 30 mins by fluorimetric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114021 BindingDB Entry DOI: 10.7270/Q2DZ0D6N |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia
Curated by ChEMBL
| Assay Description Inhibitory effect against Escherichia coli Gyrase in Supercoiling assay |
J Med Chem 39: 4952-7 (1996)
Article DOI: 10.1021/jm960414w BindingDB Entry DOI: 10.7270/Q2SX6GZP |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 3.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128499 BindingDB Entry DOI: 10.7270/Q2X06C35 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 as substrate after 30 mins by agarose gel electrophoresis |
Bioorg Med Chem Lett 28: 2477-2480 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.003 BindingDB Entry DOI: 10.7270/Q2D2218S |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 4.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of Wild Type DNA gyrase Supercoiling Activity in Escherichia coli |
J Med Chem 46: 3655-61 (2003)
Article DOI: 10.1021/jm030272n BindingDB Entry DOI: 10.7270/Q2R2144Z |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 5.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jishou University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated DNA supercoiling using relaxed pBR322 substrate incubated for 60 m... |
Bioorg Med Chem 22: 3620-8 (2014)
Article DOI: 10.1016/j.bmc.2014.05.018 BindingDB Entry DOI: 10.7270/Q2NV9N7J |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Bacillus subtilis) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB
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| DrugBank Article PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Microbiotix
| Assay Description The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%. |
Antimicrob Agents Chemother 51: 119-27 (2007)
Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 9.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against DNA gyrase from Escherichia coli H560 |
J Med Chem 48: 1229-36 (2005)
Article DOI: 10.1021/jm0401356 BindingDB Entry DOI: 10.7270/Q23B61N6 |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical University of Warsaw
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 DNA as substrate after 30 mins by ethidium bromide staining based a... |
Eur J Med Chem 156: 631-640 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.041 BindingDB Entry DOI: 10.7270/Q2VQ357Z |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 as substrate by gel electrophoresis |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00428 BindingDB Entry DOI: 10.7270/Q2Z89H4G |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus subsp. aureus Mu50) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB
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| PDB Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wockhardt Limited
Curated by ChEMBL
| Assay Description Inhibition of supercoiling activity of DNA gyrase from Staphylococcus aureus ISP 794 |
J Med Chem 48: 5232-42 (2005)
Article DOI: 10.1021/jm050035f BindingDB Entry DOI: 10.7270/Q2K0771W |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against DNA-gyrase |
J Med Chem 31: 503-6 (1988)
BindingDB Entry DOI: 10.7270/Q23B62BK |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank Article PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description Inhibition of the gyrase mediated cleavage of supercoiled DNA |
J Med Chem 36: 1964-70 (1993)
Article DOI: 10.1021/jm00066a005 BindingDB Entry DOI: 10.7270/Q2F191XX |
More data for this Ligand-Target Pair | |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 DNA as substrate incubated for 45 mins by agarose gel electrophoresis method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.111977 BindingDB Entry DOI: 10.7270/Q2QJ7MXV |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00111 BindingDB Entry DOI: 10.7270/Q2TT4W0M |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophe... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01250 BindingDB Entry DOI: 10.7270/Q2CN77R0 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 3.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Medical School
Curated by ChEMBL
| Assay Description Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyrase |
Antimicrob Agents Chemother 54: 3011-4 (2010)
Article DOI: 10.1128/AAC.00190-10 BindingDB Entry DOI: 10.7270/Q2W098SQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB
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| PDB Article PubMed
| n/a | n/a | 3.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP)
Curated by ChEMBL
| Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... |
Bioorg Med Chem 26: 4551-4559 (2018)
Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 3.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus wild type DNA gyrase |
Bioorg Med Chem 17: 6879-89 (2009)
Article DOI: 10.1016/j.bmc.2009.08.026 BindingDB Entry DOI: 10.7270/Q2M90CHK |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 3.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
King's College London
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 as substrate by gel based fluorescence assay |
J Med Chem 63: 6941-6958 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00328 BindingDB Entry DOI: 10.7270/Q21V5JHS |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 6.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus wild-type DNA gyrase supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to supercoiled ... |
Antimicrob Agents Chemother 51: 2445-53 (2007)
Article DOI: 10.1128/aac.00158-07 BindingDB Entry DOI: 10.7270/Q2QR50XQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay |
J Med Chem 50: 199-210 (2007)
Article DOI: 10.1021/jm060844e BindingDB Entry DOI: 10.7270/Q2R78J0H |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 6.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass... |
J Med Chem 54: 3268-82 (2011)
Article DOI: 10.1021/jm101604v BindingDB Entry DOI: 10.7270/Q28S4SRX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| DrugBank PDB Article PubMed
| n/a | n/a | 1.21E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge... |
J Med Chem 62: 2950-2973 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01750 BindingDB Entry DOI: 10.7270/Q2TX3JM6 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.28E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Staphylococcus aureus N-terminal His6-tagged DNA gyrase subunit GyrA/GyrB supercoiling activity expressed in Escherichia coli BL21 (DE3... |
J Med Chem 60: 3755-3775 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01834 BindingDB Entry DOI: 10.7270/Q2SQ92VF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Staphylococcus aureus) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.28E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Inhibition of wild type Staphylococcus aureus DNA gyrase subunit 2GyrA/2GyrB assessed as pBR322 supercoiling after 1 hr |
J Med Chem 56: 7396-415 (2013)
Article DOI: 10.1021/jm400963y BindingDB Entry DOI: 10.7270/Q2HT2QRV |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
DNA gyrase subunit A/B
(Escherichia coli (strain K12)) | BDBM21690
![PNG](/data/jpeg/tenK2/BindingDB_21690.png) (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)Show InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of Quinolone resistant gyrase Supercoiling Activity in Escherichia coli |
J Med Chem 46: 3655-61 (2003)
Article DOI: 10.1021/jm030272n BindingDB Entry DOI: 10.7270/Q2R2144Z |
More data for this Ligand-Target Pair | |