Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA gyrase subunit A/B (Escherichia coli (strain K12)) | BDBM4078 (6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI) | Citation and Details BindingDB Entry DOI: 10.7270/Q2FX7CM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Escherichia coli (strain K12)) | BDBM4078 (6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of DNA gyrase supercoiling in Escherichia coli. | Bioorg Med Chem Lett 8: 97-100 (1998) BindingDB Entry DOI: 10.7270/Q25141DT | |||||||||||
More data for this Ligand-Target Pair |