BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit B' and Ligand = 'BDBM50490570'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA gyrase subunit B


(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)		BDBM50490570
PNG
(CHEMBL2338469)
Show SMILES CCN1CCN(CC1C(O)=O)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1
Show InChI InChI=1S/C21H24FN3O6/c1-3-23-6-7-24(10-15(23)21(29)30)17-14(22)8-12-16(19(17)31-2)25(11-4-5-11)9-13(18(12)26)20(27)28/h8-9,11,15H,3-7,10H2,1-2H3,(H,27,28)(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+5n/an/an/an/an/an/a



Universit£ Paris Diderot

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB assessed as reduction of enzyme supercoiling activity using relaxed pBR322 DNA substrat...

Bioorg Med Chem 21: 948-56 (2013)


Article DOI: 10.1016/j.bmc.2012.12.011
BindingDB Entry DOI: 10.7270/Q2FF3W92
More data for this
Ligand-Target Pair