BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit B' and Ligand = 'BDBM50490571'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA gyrase subunit B


(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)		BDBM50490571
PNG
(CHEMBL2338471)
Show SMILES CCN(CC)C(=O)OCC1CN(CCN1)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1
Show InChI InChI=1S/C24H31FN4O6/c1-4-27(5-2)24(33)35-13-14-11-28(9-8-26-14)20-18(25)10-16-19(22(20)34-3)29(15-6-7-15)12-17(21(16)30)23(31)32/h10,12,14-15,26H,4-9,11,13H2,1-3H3,(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.01E+5n/an/an/an/an/an/a



Universit£ Paris Diderot

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB assessed as reduction of enzyme supercoiling activity using relaxed pBR322 DNA substrat...

Bioorg Med Chem 21: 948-56 (2013)


Article DOI: 10.1016/j.bmc.2012.12.011
BindingDB Entry DOI: 10.7270/Q2FF3W92
More data for this
Ligand-Target Pair