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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50202839'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50202839
PNG
(CHEMBL3968109)
Show SMILES [Br-].Fc1ccc(C[n+]2ccc3ccnc4-c5ccccc5-c2c34)cc1
Show InChI InChI=1S/C21H14FN2/c22-16-7-5-14(6-8-16)13-24-12-10-15-9-11-23-20-17-3-1-2-4-18(17)21(24)19(15)20/h1-12H,13H2/q+1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.27E+5n/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DNA topoisomerase 1 using pHOT1 as substrate after 30 mins by agarose gel electrophoresis

Bioorg Med Chem 24: 6119-6130 (2016)


Article DOI: 10.1016/j.bmc.2016.02.028
BindingDB Entry DOI: 10.7270/Q2BG2QZJ
More data for this
Ligand-Target Pair