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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha/2-beta' and Ligand = 'BDBM50471906'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50471906
PNG
(CHEMBL337205)
Show SMILES OC(=O)c1cn2c3cc4ccccc4cc3oc3c(N4CCNCC4)c(F)cc(c23)c1=O
Show InChI InChI=1S/C24H18FN3O4/c25-17-11-15-20-23(21(17)27-7-5-26-6-8-27)32-19-10-14-4-2-1-3-13(14)9-18(19)28(20)12-16(22(15)29)24(30)31/h1-4,9-12,26H,5-8H2,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

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antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 640n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of topoisomerase II as conversion of catenated to decatenated KDNA

J Med Chem 41: 4273-8 (1998)


Article DOI: 10.1021/jm980265c
BindingDB Entry DOI: 10.7270/Q25X2CPR
More data for this
Ligand-Target Pair