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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha/2-beta' and Ligand = 'BDBM50473977'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50473977
PNG
(CHEMBL538994)
Show SMILES Cl.NC1CCN(C1)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1nccs1
Show InChI InChI=1S/C16H14FN5O3S.ClH/c17-11-5-9-12(23)10(15(24)25)7-22(16-19-2-4-26-16)13(9)20-14(11)21-3-1-8(18)6-21;/h2,4-5,7-8H,1,3,6,18H2,(H,24,25);1H
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>4.85E+5n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentration

J Med Chem 45: 5564-75 (2002)


Article DOI: 10.1021/jm010057b
BindingDB Entry DOI: 10.7270/Q2XS5Z46
More data for this
Ligand-Target Pair