Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM50501614'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha (Homo sapiens (Human))	BDBM50501614 (CHEMBL583073) Show SMILES COc1ccccc1CNCCCn1c(=O)c2ccc3c4c(ccc(c24)c1=O)c(=O)n(CCCNCc1ccccc1OC)c3=O Show InChI InChI=1S/C36H36N4O6/c1-45-29-11-5-3-9-23(29)21-37-17-7-19-39-33(41)25-13-15-27-32-28(16-14-26(31(25)32)34(39)42)36(44)40(35(27)43)20-8-18-38-22-24-10-4-6-12-30(24)46-2/h3-6,9-16,37-38H,7-8,17-22H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alma Mater Studiorum-University of Bologna Curated by ChEMBL					Assay Description Inhibition of human topoisomerase-2alpha-mediated relaxation of supercoiled pBR322 DNA after 1 hr by ethidium bromide staining based agarose gel elec...				Eur J Med Chem 128: 107-122 (2017) Article DOI: 10.1016/j.ejmech.2017.01.025 BindingDB Entry DOI: 10.7270/Q2668H7X
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