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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM50505826'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50505826
PNG
(CHEMBL4552030)
Show SMILES CC(=O)Nc1ccc2c(ccnc2c1O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N2O2/c1-10(24)23-15-7-6-14-13(8-9-22-16(14)17(15)25)11-2-4-12(5-3-11)18(19,20)21/h2-9,25H,1H3,(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Colorado State University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...

J Med Chem 62: 10182-10203 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01065
BindingDB Entry DOI: 10.7270/Q2251NGG
More data for this
Ligand-Target Pair