Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209514' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209514
(US9271969, 2)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1ccc(cc1)C(F)(F)F |r,wD:4.3,(12.76,-3.85,;11.42,-3.08,;11.42,-1.54,;10.09,-3.85,;8.75,-3.08,;8.75,-1.54,;7.42,-.77,;6.09,-1.54,;6.09,-3.08,;7.42,-3.85,;4.75,-.77,;3.42,-1.54,;2.09,-.77,;2.09,.77,;3.42,1.54,;4.75,.77,;.75,1.54,;.75,3.08,;-.58,3.85,;-1.92,3.08,;-3.38,3.56,;-4.29,2.31,;-3.38,1.06,;-1.92,1.54,;-.58,.77,;-5.83,2.31,;-6.6,3.64,;-6.6,.98,;-8.14,.98,;-8.91,2.31,;-10.45,2.31,;-11.22,.98,;-10.45,-.36,;-8.91,-.36,;-12.76,.98,;-14.3,.98,;-12.76,-.56,;-12.76,2.52,)| Show InChI InChI=1S/C29H26F3N3O3/c30-29(31,32)23-10-12-24(13-11-23)33-28(38)25-17-35-16-22(9-14-26(35)34-25)21-7-5-20(6-8-21)19-3-1-18(2-4-19)15-27(36)37/h5-14,16-19H,1-4,15H2,(H,33,38)(H,36,37)/t18-,19? | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209514
(US9271969, 2)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1ccc(cc1)C(F)(F)F |r,wD:4.3,(12.76,-3.85,;11.42,-3.08,;11.42,-1.54,;10.09,-3.85,;8.75,-3.08,;8.75,-1.54,;7.42,-.77,;6.09,-1.54,;6.09,-3.08,;7.42,-3.85,;4.75,-.77,;3.42,-1.54,;2.09,-.77,;2.09,.77,;3.42,1.54,;4.75,.77,;.75,1.54,;.75,3.08,;-.58,3.85,;-1.92,3.08,;-3.38,3.56,;-4.29,2.31,;-3.38,1.06,;-1.92,1.54,;-.58,.77,;-5.83,2.31,;-6.6,3.64,;-6.6,.98,;-8.14,.98,;-8.91,2.31,;-10.45,2.31,;-11.22,.98,;-10.45,-.36,;-8.91,-.36,;-12.76,.98,;-14.3,.98,;-12.76,-.56,;-12.76,2.52,)| Show InChI InChI=1S/C29H26F3N3O3/c30-29(31,32)23-10-12-24(13-11-23)33-28(38)25-17-35-16-22(9-14-26(35)34-25)21-7-5-20(6-8-21)19-3-1-18(2-4-19)15-27(36)37/h5-14,16-19H,1-4,15H2,(H,33,38)(H,36,37)/t18-,19? | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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