Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209528' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209528
(US9271969, 16)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1cccc(Cl)c1 |r,wD:4.3,(9.68,-5.75,;8.34,-4.98,;8.34,-3.44,;7.01,-5.75,;5.67,-4.98,;5.67,-3.44,;4.34,-2.67,;3.01,-3.44,;3.01,-4.98,;4.34,-5.75,;1.67,-2.67,;.34,-3.44,;-.99,-2.67,;-.99,-1.13,;.34,-.36,;1.67,-1.13,;-2.33,-.36,;-2.33,1.18,;-3.66,1.95,;-5,1.18,;-6.46,1.66,;-7.37,.41,;-6.46,-.83,;-5,-.36,;-3.66,-1.13,;-8.91,.41,;-9.68,-.92,;-9.68,1.75,;-8.91,3.08,;-9.68,4.41,;-8.91,5.75,;-7.37,5.75,;-6.6,4.41,;-5.06,4.41,;-7.37,3.08,)| Show InChI InChI=1S/C28H26ClN3O3/c29-23-2-1-3-24(15-23)30-28(35)25-17-32-16-22(12-13-26(32)31-25)21-10-8-20(9-11-21)19-6-4-18(5-7-19)14-27(33)34/h1-3,8-13,15-19H,4-7,14H2,(H,30,35)(H,33,34)/t18-,19? | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209528
(US9271969, 16)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1cccc(Cl)c1 |r,wD:4.3,(9.68,-5.75,;8.34,-4.98,;8.34,-3.44,;7.01,-5.75,;5.67,-4.98,;5.67,-3.44,;4.34,-2.67,;3.01,-3.44,;3.01,-4.98,;4.34,-5.75,;1.67,-2.67,;.34,-3.44,;-.99,-2.67,;-.99,-1.13,;.34,-.36,;1.67,-1.13,;-2.33,-.36,;-2.33,1.18,;-3.66,1.95,;-5,1.18,;-6.46,1.66,;-7.37,.41,;-6.46,-.83,;-5,-.36,;-3.66,-1.13,;-8.91,.41,;-9.68,-.92,;-9.68,1.75,;-8.91,3.08,;-9.68,4.41,;-8.91,5.75,;-7.37,5.75,;-6.6,4.41,;-5.06,4.41,;-7.37,3.08,)| Show InChI InChI=1S/C28H26ClN3O3/c29-23-2-1-3-24(15-23)30-28(35)25-17-32-16-22(12-13-26(32)31-25)21-10-8-20(9-11-21)19-6-4-18(5-7-19)14-27(33)34/h1-3,8-13,15-19H,4-7,14H2,(H,30,35)(H,33,34)/t18-,19? | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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