Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209559' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209559
(US9271969, 47)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)Nc1cccc(Cl)c1 |r,wU:7.10,wD:4.3,(10.07,-.67,;8.53,-.67,;7.76,.67,;7.76,-2,;6.22,-2,;5.45,-.67,;3.91,-.67,;3.14,-2,;3.91,-3.33,;5.45,-3.33,;1.6,-2,;.83,-3.33,;-.71,-3.33,;-1.48,-2,;-.71,-.67,;.83,-.67,;-3.02,-2,;-3.93,-3.25,;-5.39,-2.77,;-6.85,-3.25,;-7.76,-2,;-6.85,-.75,;-5.39,-1.23,;-3.93,-.75,;-9.3,-2,;-10.07,-3.33,;-10.07,-.67,;-9.3,.67,;-10.07,2,;-9.3,3.33,;-7.76,3.33,;-6.99,2,;-5.45,2,;-7.76,.67,)| Show InChI InChI=1S/C26H24ClN3O3S/c27-20-2-1-3-21(13-20)28-25(33)22-14-30-15-23(34-26(30)29-22)19-10-8-18(9-11-19)17-6-4-16(5-7-17)12-24(31)32/h1-3,8-11,13-17H,4-7,12H2,(H,28,33)(H,31,32)/t16-,17- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209559
(US9271969, 47)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)Nc1cccc(Cl)c1 |r,wU:7.10,wD:4.3,(10.07,-.67,;8.53,-.67,;7.76,.67,;7.76,-2,;6.22,-2,;5.45,-.67,;3.91,-.67,;3.14,-2,;3.91,-3.33,;5.45,-3.33,;1.6,-2,;.83,-3.33,;-.71,-3.33,;-1.48,-2,;-.71,-.67,;.83,-.67,;-3.02,-2,;-3.93,-3.25,;-5.39,-2.77,;-6.85,-3.25,;-7.76,-2,;-6.85,-.75,;-5.39,-1.23,;-3.93,-.75,;-9.3,-2,;-10.07,-3.33,;-10.07,-.67,;-9.3,.67,;-10.07,2,;-9.3,3.33,;-7.76,3.33,;-6.99,2,;-5.45,2,;-7.76,.67,)| Show InChI InChI=1S/C26H24ClN3O3S/c27-20-2-1-3-21(13-20)28-25(33)22-14-30-15-23(34-26(30)29-22)19-10-8-18(9-11-19)17-6-4-16(5-7-17)12-24(31)32/h1-3,8-11,13-17H,4-7,12H2,(H,28,33)(H,31,32)/t16-,17- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <150 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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