Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209561' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209561
(US9271969, 49)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NCc1ccc(F)c(Cl)c1 |r,wU:7.10,wD:4.3,(11.19,-2,;9.72,-2,;8.95,-.67,;8.95,-3.33,;7.41,-3.33,;6.64,-2,;5.1,-2,;4.33,-3.33,;5.1,-4.67,;6.64,-4.67,;2.79,-3.33,;2.02,-4.67,;.48,-4.67,;-.29,-3.33,;.48,-2,;2.02,-2,;-1.83,-3.33,;-2.74,-4.58,;-4.2,-4.1,;-5.66,-4.58,;-6.57,-3.33,;-5.66,-2.09,;-4.2,-2.56,;-2.74,-2.09,;-8.11,-3.33,;-8.88,-4.67,;-8.88,-2,;-8.11,-.67,;-8.88,.67,;-10.42,.67,;-11.19,2,;-10.42,3.33,;-11.19,4.67,;-8.88,3.33,;-8.11,4.67,;-8.11,2,)| Show InChI InChI=1S/C27H25ClFN3O3S/c28-21-11-17(3-10-22(21)29)13-30-26(35)23-14-32-15-24(36-27(32)31-23)20-8-6-19(7-9-20)18-4-1-16(2-5-18)12-25(33)34/h3,6-11,14-16,18H,1-2,4-5,12-13H2,(H,30,35)(H,33,34)/t16-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209561
(US9271969, 49)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NCc1ccc(F)c(Cl)c1 |r,wU:7.10,wD:4.3,(11.19,-2,;9.72,-2,;8.95,-.67,;8.95,-3.33,;7.41,-3.33,;6.64,-2,;5.1,-2,;4.33,-3.33,;5.1,-4.67,;6.64,-4.67,;2.79,-3.33,;2.02,-4.67,;.48,-4.67,;-.29,-3.33,;.48,-2,;2.02,-2,;-1.83,-3.33,;-2.74,-4.58,;-4.2,-4.1,;-5.66,-4.58,;-6.57,-3.33,;-5.66,-2.09,;-4.2,-2.56,;-2.74,-2.09,;-8.11,-3.33,;-8.88,-4.67,;-8.88,-2,;-8.11,-.67,;-8.88,.67,;-10.42,.67,;-11.19,2,;-10.42,3.33,;-11.19,4.67,;-8.88,3.33,;-8.11,4.67,;-8.11,2,)| Show InChI InChI=1S/C27H25ClFN3O3S/c28-21-11-17(3-10-22(21)29)13-30-26(35)23-14-32-15-24(36-27(32)31-23)20-8-6-19(7-9-20)18-4-1-16(2-5-18)12-25(33)34/h3,6-11,14-16,18H,1-2,4-5,12-13H2,(H,30,35)(H,33,34)/t16-,18- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <25 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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