Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209572' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209572
(US9271969, 60)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)Nc1ccc(F)c(Cl)c1 |r,wD:4.3,(10.07,-1.33,;8.53,-1.33,;7.76,,;7.76,-2.67,;6.22,-2.67,;5.45,-1.33,;3.91,-1.33,;3.14,-2.67,;3.91,-4,;5.45,-4,;1.6,-2.67,;.83,-4,;-.71,-4,;-1.48,-2.67,;-.71,-1.33,;.83,-1.33,;-3.02,-2.67,;-3.93,-3.91,;-5.39,-3.44,;-6.85,-3.91,;-7.76,-2.67,;-6.85,-1.42,;-5.39,-1.9,;-3.93,-1.42,;-9.3,-2.67,;-10.07,-4,;-10.07,-1.33,;-9.3,,;-7.76,,;-6.99,1.33,;-7.76,2.67,;-6.99,4,;-9.3,2.67,;-10.07,4,;-10.07,1.33,)| Show InChI InChI=1S/C26H23ClFN3O3S/c27-20-12-19(9-10-21(20)28)29-25(34)22-13-31-14-23(35-26(31)30-22)18-7-5-17(6-8-18)16-3-1-15(2-4-16)11-24(32)33/h5-10,12-16H,1-4,11H2,(H,29,34)(H,32,33)/t15-,16? | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209572
(US9271969, 60)Show SMILES OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)Nc1ccc(F)c(Cl)c1 |r,wD:4.3,(10.07,-1.33,;8.53,-1.33,;7.76,,;7.76,-2.67,;6.22,-2.67,;5.45,-1.33,;3.91,-1.33,;3.14,-2.67,;3.91,-4,;5.45,-4,;1.6,-2.67,;.83,-4,;-.71,-4,;-1.48,-2.67,;-.71,-1.33,;.83,-1.33,;-3.02,-2.67,;-3.93,-3.91,;-5.39,-3.44,;-6.85,-3.91,;-7.76,-2.67,;-6.85,-1.42,;-5.39,-1.9,;-3.93,-1.42,;-9.3,-2.67,;-10.07,-4,;-10.07,-1.33,;-9.3,,;-7.76,,;-6.99,1.33,;-7.76,2.67,;-6.99,4,;-9.3,2.67,;-10.07,4,;-10.07,1.33,)| Show InChI InChI=1S/C26H23ClFN3O3S/c27-20-12-19(9-10-21(20)28)29-25(34)22-13-31-14-23(35-26(31)30-22)18-7-5-17(6-8-18)16-3-1-15(2-4-16)11-24(32)33/h5-10,12-16H,1-4,11H2,(H,29,34)(H,32,33)/t15-,16? | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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