Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209576' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209576
(US9271969, 64)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NCc1c(F)cc(Cl)cc1F |r,wU:7.10,wD:4.3,(12.38,3.33,;10.84,3.33,;10.07,4.67,;10.07,2,;8.53,2,;7.76,3.33,;6.22,3.33,;5.45,2,;6.22,.67,;7.76,.67,;3.91,2,;3.14,3.33,;1.6,3.33,;.83,2,;1.6,.67,;3.14,.67,;-.71,2,;-1.62,.75,;-3.08,1.23,;-4.54,.75,;-5.45,2,;-4.54,3.25,;-3.08,2.77,;-1.62,3.25,;-6.99,2,;-7.76,3.33,;-7.76,.67,;-9.3,.67,;-10.07,-.67,;-11.61,-.67,;-12.38,.67,;-12.38,-2,;-11.61,-3.33,;-12.38,-4.67,;-10.07,-3.33,;-9.3,-2,;-7.76,-2,)| Show InChI InChI=1S/C27H24ClF2N3O3S/c28-19-10-21(29)20(22(30)11-19)12-31-26(36)23-13-33-14-24(37-27(33)32-23)18-7-5-17(6-8-18)16-3-1-15(2-4-16)9-25(34)35/h5-8,10-11,13-16H,1-4,9,12H2,(H,31,36)(H,34,35)/t15-,16- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209576
(US9271969, 64)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cn2cc(nc2s1)C(=O)NCc1c(F)cc(Cl)cc1F |r,wU:7.10,wD:4.3,(12.38,3.33,;10.84,3.33,;10.07,4.67,;10.07,2,;8.53,2,;7.76,3.33,;6.22,3.33,;5.45,2,;6.22,.67,;7.76,.67,;3.91,2,;3.14,3.33,;1.6,3.33,;.83,2,;1.6,.67,;3.14,.67,;-.71,2,;-1.62,.75,;-3.08,1.23,;-4.54,.75,;-5.45,2,;-4.54,3.25,;-3.08,2.77,;-1.62,3.25,;-6.99,2,;-7.76,3.33,;-7.76,.67,;-9.3,.67,;-10.07,-.67,;-11.61,-.67,;-12.38,.67,;-12.38,-2,;-11.61,-3.33,;-12.38,-4.67,;-10.07,-3.33,;-9.3,-2,;-7.76,-2,)| Show InChI InChI=1S/C27H24ClF2N3O3S/c28-19-10-21(29)20(22(30)11-19)12-31-26(36)23-13-33-14-24(37-27(33)32-23)18-7-5-17(6-8-18)16-3-1-15(2-4-16)9-25(34)35/h5-8,10-11,13-16H,1-4,9,12H2,(H,31,36)(H,34,35)/t15-,16- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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