Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM209577' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM209577
(US9271969, 65)Show SMILES CC(C)([C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)NCc1ccccc1)C(O)=O |r,wD:3.2,(8.55,-6.41,;9.32,-5.08,;10.09,-6.41,;7.98,-4.31,;7.98,-2.77,;6.65,-2,;5.32,-2.77,;5.32,-4.31,;6.65,-5.08,;3.98,-2,;2.65,-2.77,;1.32,-2,;1.32,-.46,;2.65,.31,;3.98,-.46,;-.02,.31,;-.02,1.85,;-1.35,2.62,;-2.69,1.85,;-4.15,2.33,;-5.06,1.08,;-4.15,-.17,;-2.69,.31,;-1.35,-.46,;-6.6,1.08,;-7.37,-.25,;-7.37,2.41,;-8.91,2.41,;-9.68,3.75,;-8.91,5.08,;-9.68,6.41,;-11.22,6.41,;-11.99,5.08,;-11.22,3.75,;10.65,-4.31,;11.99,-5.08,;10.65,-2.77,)| Show InChI InChI=1S/C31H33N3O3/c1-31(2,30(36)37)26-15-12-23(13-16-26)22-8-10-24(11-9-22)25-14-17-28-33-27(20-34(28)19-25)29(35)32-18-21-6-4-3-5-7-21/h3-11,14,17,19-20,23,26H,12-13,15-16,18H2,1-2H3,(H,32,35)(H,36,37)/t23?,26- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM209577
(US9271969, 65)Show SMILES CC(C)([C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)NCc1ccccc1)C(O)=O |r,wD:3.2,(8.55,-6.41,;9.32,-5.08,;10.09,-6.41,;7.98,-4.31,;7.98,-2.77,;6.65,-2,;5.32,-2.77,;5.32,-4.31,;6.65,-5.08,;3.98,-2,;2.65,-2.77,;1.32,-2,;1.32,-.46,;2.65,.31,;3.98,-.46,;-.02,.31,;-.02,1.85,;-1.35,2.62,;-2.69,1.85,;-4.15,2.33,;-5.06,1.08,;-4.15,-.17,;-2.69,.31,;-1.35,-.46,;-6.6,1.08,;-7.37,-.25,;-7.37,2.41,;-8.91,2.41,;-9.68,3.75,;-8.91,5.08,;-9.68,6.41,;-11.22,6.41,;-11.99,5.08,;-11.22,3.75,;10.65,-4.31,;11.99,-5.08,;10.65,-2.77,)| Show InChI InChI=1S/C31H33N3O3/c1-31(2,30(36)37)26-15-12-23(13-16-26)22-8-10-24(11-9-22)25-14-17-28-33-27(20-34(28)19-25)29(35)32-18-21-6-4-3-5-7-21/h3-11,14,17,19-20,23,26H,12-13,15-16,18H2,1-2H3,(H,32,35)(H,36,37)/t23?,26- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <125 | n/a | n/a | n/a | n/a | 7.4 | 25 |
KAINOS MEDICINE, INC.
US Patent
| Assay Description
Assay buffer [20 mM HEPES (pH 7.4), 100 mM MgCl2 and 0.04% bovine serum albumin (BSA)] containing 500 uM of enzyme substrate (didecanoyl glycerol) ... |
US Patent US9271969 (2016)
BindingDB Entry DOI: 10.7270/Q2057DS8 |
More data for this
Ligand-Target Pair | |
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