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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM395379'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Homo sapiens (Human))		BDBM395379
PNG
(US10308636, Example 72)
Show SMILES COC(=O)C(C)(C)COc1ccc(cn1)-c1ccc(cc1)-c1nc(Oc2cccnc2)n(COCC[Si](C)(C)C)n1
Show InChI InChI=1S/C30H37N5O5Si/c1-30(2,28(36)37-3)20-39-26-14-13-24(18-32-26)22-9-11-23(12-10-22)27-33-29(40-25-8-7-15-31-19-25)35(34-27)21-38-16-17-41(4,5)6/h7-15,18-19H,16-17,20-21H2,1-6H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Wyeth Research



Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...

Bioorg Med Chem Lett 19: 3485-8 (2009)


BindingDB Entry DOI: 10.7270/Q28S4S76
More data for this
Ligand-Target Pair