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Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50385418'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Homo sapiens (Human))		BDBM50385418
PNG
(CHEMBL2036590)
Show SMILES Fc1ccc(Nc2nnc(o2)C(=O)Nc2ccc(nc2)N2CCOCC2)cc1F
Show InChI InChI=1S/C18H16F2N6O3/c19-13-3-1-11(9-14(13)20)23-18-25-24-17(29-18)16(27)22-12-2-4-15(21-10-12)26-5-7-28-8-6-26/h1-4,9-10H,5-8H2,(H,22,27)(H,23,25)
PDB

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PC sid
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Similars
Article
PubMed
n/an/a 340n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...

Bioorg Med Chem Lett 22: 3873-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.117
BindingDB Entry DOI: 10.7270/Q2T72JG4
More data for this
Ligand-Target Pair