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Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50385421'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Homo sapiens (Human))		BDBM50385421
PNG
(CHEMBL2036593)
Show SMILES Clc1ccc(Nc2nnc(o2)C(=O)Nc2ccc(nc2)N2CCOCC2)cc1
Show InChI InChI=1S/C18H17ClN6O3/c19-12-1-3-13(4-2-12)22-18-24-23-17(28-18)16(26)21-14-5-6-15(20-11-14)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,21,26)(H,22,24)
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation...

Bioorg Med Chem Lett 22: 3873-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.117
BindingDB Entry DOI: 10.7270/Q2T72JG4
More data for this
Ligand-Target Pair