Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1 [89-488]' and Ligand = 'BDBM120767'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 [89-488] (Homo sapiens (Human))	BDBM120767 (US8703761, 6-1) Show SMILES CC(C)(NC(=O)c1ccc(OC(F)(F)F)cc1)C(=O)Nc1nc(c(Oc2ccc(F)cc2)s1)-c1ccc(F)cc1 Show InChI InChI=1S/C27H20F5N3O4S/c1-26(2,35-22(36)16-5-11-20(12-6-16)39-27(30,31)32)24(37)34-25-33-21(15-3-7-17(28)8-4-15)23(40-25)38-19-13-9-18(29)10-14-19/h3-14H,1-2H3,(H,35,36)(H,33,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	910	n/a	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description The enzyme preparation used in this assay is a membrane preparation from Sf9 cells overexpressing human (His)6DGAT1. During all steps samples were ch...				US Patent US8703761 (2014) BindingDB Entry DOI: 10.7270/Q2057DM1
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