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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM360438'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM360438
PNG
(8-((isoquinoline-1- carboxamido)methyl)-5-(3- (met...)
Show SMILES OCC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2nccc3ccccc23)c2cnccc12
Show InChI InChI=1S/C28H21N3O3/c32-17-26(33)20-6-3-5-19(14-20)22-9-8-21(25-16-29-12-11-24(22)25)15-31-28(34)27-23-7-2-1-4-18(23)10-13-30-27/h1-14,16,32H,15,17H2,(H,31,34)
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US Patent
n/an/a 164n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US9828369 (2017)


BindingDB Entry DOI: 10.7270/Q2DN47C7
More data for this
Ligand-Target Pair