Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM486418'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM486418 (3-(2,6-difluorophenyl)-N-(1,1- dioxidotetrahydroth...) Show SMILES Fc1ccc(cc1)-n1cc(-c2c(F)cccc2F)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |(6.35,-6.37,;5.87,-4.91,;6.9,-3.76,;6.43,-2.3,;4.92,-1.98,;3.89,-3.12,;4.37,-4.59,;4.45,-.51,;5.35,.73,;4.45,1.98,;4.92,3.44,;3.89,4.59,;2.38,4.27,;4.37,6.05,;5.87,6.37,;6.9,5.23,;6.43,3.76,;7.46,2.62,;2.98,1.5,;1.65,2.27,;.31,1.5,;.31,-.04,;1.65,-.81,;2.98,-.04,;-1.02,-.81,;-1.02,-2.35,;-2.35,-.04,;-3.69,-.81,;-3.85,-2.34,;-5.35,-2.66,;-6.12,-1.33,;-7.46,-.56,;-7.46,-2.1,;-5.09,-.18,)| Show InChI InChI=1S/C25H19F3N2O3S/c26-16-5-7-18(8-6-16)30-13-20(24-21(27)2-1-3-22(24)28)19-9-4-15(12-23(19)30)25(31)29-17-10-11-34(32,33)14-17/h1-9,12-13,17H,10-11,14H2,(H,29,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10947222 (2021) BindingDB Entry DOI: 10.7270/Q20P134X
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