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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM486432'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM486432
PNG
(US10947222, Example 60 | methyl 4-{6-[(1,1- dioxid...)
Show SMILES COC(=O)c1cc(cs1)-c1cn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)NC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H21FN2O5S2/c1-33-25(30)23-11-16(13-34-23)21-12-28(19-5-3-17(26)4-6-19)22-10-15(2-7-20(21)22)24(29)27-18-8-9-35(31,32)14-18/h2-7,10-13,18H,8-9,14H2,1H3,(H,27,29)
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PC cid
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US Patent
n/an/a 175n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US10947222 (2021)


BindingDB Entry DOI: 10.7270/Q20P134X
More data for this
Ligand-Target Pair